Re: Association of a Common Variant of the CASP8 Gene With Reduced Risk of Breast Cancer
Open Access
- 6 July 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 97 (13) , 1012
- https://doi.org/10.1093/jnci/dji178
Abstract
Recently, MacPherson et al. ( 1 ) reported an association between the common caspase-8 (CASP8) gene variant D302H and reduced breast cancer risk. They studied two independent U.K. cohorts from Sheffield and East Anglia and observed statistically significant lower frequencies of the CASP8 DH and HH genotypes in both case patient populations compared with the respective control subjects, considering D302H as causative variant in a dose-dependent manner.Keywords
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