THE EFFECT OF METHYL XANTHINES ON THE FORMATION OF UREA IN RABBITS
- 1 October 1946
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 147 (2) , 428-431
- https://doi.org/10.1152/ajplegacy.1946.147.2.428
Abstract
Caffeine, theobromine or theophylline injected into rabbits cause a decrease in the total and urea N of the urine, with no consistent variation in the concn. of the other nitrogenous compds., and a decrease in the non-protein and urea N of the blood. Tolerance to this effect is gradually developed. Yeast pentnucleotides have a similar effect. Two women on an approx. standard diet were given 0.3 g. of theobromine 3 times a day for 3 days. In the control period of 5 days their total urinary N excretion varied from 8.4-10.1 gs. and 10.9-12.4 gs., respectively. Following the theobromine, the total N excretion decreased until on the 3d day it was 6.6 and 8.0 gs., respectively. After another control period theophylline was given in the same dosage. The total N excretion again decreased to 5.4 and 6.0 gs., respectively. In both instances the urea N fell proportionately.This publication has 0 references indexed in Scilit: