Two δ-Chain Abnormal Hemoglobins in One Individual
Open Access
- 1 November 1965
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 26 (5) , 677-681
- https://doi.org/10.1182/blood.v26.5.677.677
Abstract
Two abnormal minor hemoglobin components have been detected in the blood of a healthy Negro male. One component which was identified as the δ-chain abnormality Hb-A2' was inherited from the mother, whereas the second component, being identical with Hb-FlatbushGa, was inherited from the father. The complete absence of Hb-A2 in this individual definitely establishes the relationship of allelism between Hb-A2 and Hb-FlatbushGa. Hb-FlatbushGa, therefore, is the second hemoglobin abnormality for which indirect proof for allelism with Hb-A2 has been obtained; the discovery of three homozygous carriers of Hb-A2' (2 of these cases have been mentioned before,4 showing complete absence of Hb-A2) already established a similar relationship between Hb-A2 and Hb-A2'.This publication has 1 reference indexed in Scilit: