Production of Fever by Influenzal Viruses. IV. Tolerance to Mumps and Influenza Pyrogens

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Abstract
The fever-producing capacities of mumps and the PR8 strain of influenza viruses were studied in animals pretreated with the heterologous strain. Intraven. injn. of mumps virus causes a febrile response in rabbits similar to that produced by influenza or Newcastle disease viruses. Animals are partially or completely resistant to a 2d injection of mumps virus 24 hrs. later. Pretreatment with the PR8 strain in influenza A virus also inhibits the febrile response to mumps virus. Mumps virus itself is equally effective in producing tolerance to the PR8 strain.

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