EFFECTS OF DISCONTINUING ADMINISTRATION OF HIGH LEVELS OF 2-ACETYLAMINOFLUORENE ON THE TRANSITIONAL EPITHELIUM OF THE MOUSE URINARY-BLADDER

  • 1 January 1978
    • journal article
    • research article
    • Vol. 1  (5) , 581-585
Abstract
The effects of discontinuing the administration of a high level of 2-acetylaminofluorene (2-AFF) on the transitional epithelium of the urinary bladder of BALB/c mice was investigated. Mice were fed 500 ppm of 2-AAF for 6 and 13 wk and sacrificed at periodic intervals after discontinuing the compound. Urothelial hyperplasia regressed slower in the animals receiving the 2-AAF for 13 wk than those receiving 2-AAF for only 6 wk. A small number of bladder carcinomas were seen in the animals fed 2-AAF for 13 wk and sacrificed at 26 and 39 wk. Exposure to a high level of a carcinogen even for a relatively brief period may result in the development of carcinomas after the cessation of exposure.

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