SCANNING MICROFLUORIMETRIC STUDIES OF ANTICHOLINERGIC DRUGS IN SCHISTOSOMA-MANSONI

  • 1 January 1978
    • journal article
    • research article
    • Vol. 207  (3) , 992-997
Abstract
A microfluorimetric technique was used to analyze fluorescence in specimens of Schistosoma mansoni labeled with a dansylated analog of acetylcholine. Anticholinergic drugs inhibit the fluorescent labeling of living specimens. The effectiveness of anticholinergic agents can be expressed as a fractional decrease in observed fluorescence of specimens and several drugs were compared in this context. Atropine, eserine, carbachol and mecamylamine block fluorescence only at high concentrations (10-4-10-3 M); trifluoperazine and hycanthone strongly block at lower concentrations (10-5 M). The relative activity of anticholinergic drugs is different in schistosomes and vertebrates.

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