Induction of apoptosis in a T lymphoblastoid cell line infected with feline immunodeficiency virus
- 1 March 1994
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 135 (1-2) , 153-158
- https://doi.org/10.1007/bf01309772
Abstract
The mechanism of cell death induced by feline immunodeficiency virus (FIV) infection was investigated in an interleukin 2(IL-2)-dependent T-lymphoblastoid cell line (MYA-1). DNA extracted from FIV-infected MYA-1 cells showed a ladder of nucleosomal DNA, indicating that the cytopathic effect (CPE) observed in these cells was due to apoptosis. Infection of MYA-1 cells with FIV was associated with suppression of the proliferative response of the cells to exogenous IL-2 prior to DNA fragmentation. These findings suggest that FIV-induced CPE in these T-lymhoblastoid cells is associated with apoptosis possibly due to a defect in the IL-2 signal transduction pathway.Keywords
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