Intracellular Trafficking of Sterols
- 1 January 1990
- book chapter
- Published by Springer Nature
- Vol. 16, 301-331
- https://doi.org/10.1007/978-1-4899-1621-1_10
Abstract
Sterols are almost universally found as major membrane components of eukaryotic cells but are absent among prokaryotes. Whereas prokaryotic cells contain only a plasma membrane, eukaryotes have evolved an elaborate network of membrane-bounded organelles, or “membranelles,” in addition to the plasma membrane. Interestingly, the majority of cellular free cholesterol resides in the plasma membrane, with cholesterol-to-phospholipid (C/P) ratios several-fold higher than those of intracellular membranes. Thus, the lipid aspect of intracellular membranes of eukaryotes biochemically resembles the prokaryotic plasma membrane.Keywords
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