Comparative haemodynamic and metabolic effects of vasodilator and inotropic agents in experimental myocardial infarction
- 1 May 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 12 (5) , 294-302
- https://doi.org/10.1093/cvr/12.5.294
Abstract
Following coronary embolisation and onset of left ventricular failure 27 awake dogs were randomly assigned to infusion of saline (controls), nitroprusside, or dobutamine (a new inotropic agent). Nitroprusside and dobutamine both increased cardiac output and lowered left ventricular filling pressure while raising coronary sinus flow. Dobutamine, however, increased myocardial oxygen consumption whereas nitroprusside reduced it. Therefore vasodilators may be more beneficial than inotropic agents in acute myocardial infarction.Keywords
This publication has 1 reference indexed in Scilit:
- Dobutamine: development of a new catecholamine to selectively increase cardiac contractility.Circulation Research, 1975