EXPERIMENTAL HYPERSPLENISM IN MICE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 25  (2) , 167-172
Abstract
Experimental hypersplenism in mice was induced with repeated i.p. injections of methylcellulose. Detailed hematological tests of the peripheral blood, a cytomorphological examination of bone marrow and spleen from puncture material and histological tests of the bone marrow, spleen, lymph nodes, thymus, liver, kidneys and lung tissue of hypersplenic mice were carried out. Marked erythrocyto-, leucocyto- and thrombocytopenia were found along with lowered osmotic resistance and elevated phagocytic activity of the leukocytes of hypersplenic mice.

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