Effect of prostaglandin E1 on renal hemodynamics, sodium and water excretion

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Abstract
Prostaglandin E1 [PGE1] (0.01-2.0 [mu]g/min) was infused into the left renal artery of anesthesized 18- to 25-kg dogs. Urine volume, urinary Na excretion, free water clearance, and renal plasma flow increased on the infused side as compared to its own control values and simultaneous values from the noninfused kidney. Glomerular filtration rate and mean aortic pressure remained stable. PAH [p-amino-hyperuvate] extraction fell on the infused side. These effects may be mediated by increased renal, possibly noncortical, blood flow or by an anti-ADH [anti-anti-diuretic hormone] action of PGE1. A direct tubular action cannot be excluded. Despite systemic vasopressin infusion in one group of animals, unilateral increases in free water clearance occurred. This effect could not be dissociated from the hemodynamic and natriuretic effects. The natural occurrence of prostaglandins in the kidney and the changes noted in these experiments suggest that a prostaglandin (perhaps prostaglandin E1) may have a physiological role in the intrarenal regulation of Na and water excretion.

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