Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line
- 1 March 1985
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 314 (6009) , 330-334
- https://doi.org/10.1038/314330a0
Abstract
Two genes that code for a hapten-specific immunoglobulin M (IgM) have been introduced into the mouse germ line. The transgenic antibody represents 10–50% of the serum IgM and is expressed on the membrane of B cells. B-cell hybridoma lines show that a negative feedback inhibition of μ and κ transgenic products on the immunoglobulin heavy-chain rearrangement is possible.Keywords
This publication has 29 references indexed in Scilit:
- Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibodyCell, 1984
- High expression of cloned immunoglobulin k gene in transgenic mice is restricted to B lymphocytesNature, 1984
- Expression of a microinjected immunoglobulin gene in the spleen of transgenic miceNature, 1983
- Metallothionein-Human GH Fusion Genes Stimulate Growth of MiceScience, 1983
- Somatic generation of antibody diversityNature, 1983
- Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspringCell, 1982
- Introduction of a rabbit β-globin gene into the mouse germ lineNature, 1981
- Rearrangements of Immunoglobulin Genes during Differentiation and EvolutionImmunological Reviews, 1981
- Organization and Expression of Murine Immunoglobulin GenesImmunological Reviews, 1981
- The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.Proceedings of the National Academy of Sciences, 1981