The Conformation of Fibrinogen and Fibrin: An Electron Microscope Study

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Abstract
A mica adsorption technique was used to prepare fibrinogen [human] and early fibrin polymers for examination in the transmission electron microscope. Globular particles 10 .+-. 3 nm in diameter were observed and a model for the process of aggregation of these globules into fibrous units is proposed. A comparison is made between the results obtained by the mica adsorption technique and those obtained by conventional preparation techniques involving fixation and staining.