Effect of p-Chloromercuribenzene Sulfonate on Lens Cation Transport

1 January 1978

journal article
research article
Published by S. Karger AG in Ophthalmic Research

Vol. 10 (1) , 41-46
https://doi.org/10.1159/000264933

Abstract

The effect of p-chloromercuribenzene sulfonate (PCMBS) on the lens cation transport system was studied. PCMBS was used since this reagent was reported to act primarily on the sulfhydryl (-SH) groups of the surface membranes. PCMBS decreased the accumulation of labeled RB+ in rat lens. Under certain conditions, PCMBS affected the Rb+ accumulation without affecting the levels of reduced glutathione or ATP, indicating that the reagent did not enter the lens fibers. Apparently -SH groups in the lens membranes do influence the cation transport mechanism.

Keywords

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