Effects of Cigarette Smoke on Hamsters

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Abstract
Groups of male hamsters were exposed to cigarette smoke 100 times to a total of 3,000 or 6,000 cigarettes. In comparison to control groups it was found that exposure to cigarette smoke, to the gaseous phase, or to 4% carbon monoxide (CO) in air resulted in a decrease of skin temperature for both smoke-adapted and non-smoke-adapted hamsters. Hamsters exposed to cigarette smoke or to the gaseous phase achieved and maintained a significantly lower body weight. Reversibility of the effect could be demonstrated after cessation of smoking. Exposure to cigarette smoke resulted in an increase in erythrocyte counts from the 50th day which persisted six weeks after the last exposure. Food consumption of exposed hamsters was approximately 27% less than that of controls. Leukocyte counts, sedimentation rate, and the amount of drinking water consumed were not affected significantly.

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