Specific calcium-dependent release of endogenous glutamate from rat striatum is reduced by destruction of the cortico-striatal tract
- 1 May 1980
- journal article
- Published by Springer Nature in Experimental Brain Research
- Vol. 39 (2) , 239-240
- https://doi.org/10.1007/bf00237555
Abstract
Rat neostriatal slices exhibited a Ca2+-dependent release of endogenous glutamate when depolarized by elevated K+. This evoked release was reduced by 30% in tissue from animals subjected to fronto-parietal lesions 3 weeks previously. These results support the proposal that glutamate is the transmitter of the cortico-striatal pathway.Keywords
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