Stereoselective Cyclization of cis-Decalin Skeleton of Vinigrol via Ketyl-Olefin Coupling Promoted by Samarium(II) Iodide

Abstract
The cis-decalin ring system of vinigrol, a unique tricyclic diterpene isolated as a novel antihypertensive compound from a culture broth of Virgaria nigra, was synthesized featuring a ketyl-olefin coupling annulation reaction induced by SmI2.

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