NUCLEOSIDE ANALOGS AS NON-SUBSTRATE INHIBITORS OF HERPES-SIMPLEX VIRUSES THYMIDINE KINASE
- 1 September 1989
- journal article
- research article
- Vol. 11 (9) , 577-582
Abstract
We have examined the capacity of a series of 6-substituted pyrimidine and 2-substituted purine derivatives to inhibit mammalian thymidine kinase and the thymidine kinases encoded by type 1 and 2 herpes simplex viruses. Several N2-substituted guanine and deoxy guanosine derivatives displayed selective inhibitory activity against the HSV-1 and HSV-2 thymidine kinases by competing with the phosphorylation of thymidine, suggesting a possible novel pharmacological approach to herpes viruses infections.This publication has 2 references indexed in Scilit:
- N2-Phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymiding kinaseJournal of Medicinal Chemistry, 1988
- Synthesis, cell-growth inhibition, and antitumor screening of 2-(p-n-butylanilino)purines and their nucleoside analogsJournal of Medicinal Chemistry, 1987