Lentivirus Lytic Peptide 1 Perturbs both Outer and Inner Membranes of Serratia marcescens
Open Access
- 1 June 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (6) , 2041-2045
- https://doi.org/10.1128/aac.46.6.2041-2045.2002
Abstract
Bis-lentivirus lytic protein 1 (Bis-LLP1) and polymyxin B exhibited similar killing activities against Serratia marcescens. By electron microscopy, bis-LLP1 interacted with the outer and cytoplasmic bacterial membranes, while polymyxin B affected only the outer membrane. The results of standard biochemical probes supported the findings of the electron microscopy studies, suggesting that these antimicrobial peptides have different mechanisms of action.Keywords
This publication has 14 references indexed in Scilit:
- Interactions of Bacterial Cationic Peptide Antibiotics with Outer and Cytoplasmic Membranes of Pseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 2000
- Cationic antimicrobial peptides: towards clinical applicationsExpert Opinion on Investigational Drugs, 2000
- The interaction of the antimicrobial peptide gramicidin S with lipid bilayer model and biological membranesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1999
- Lentivirus-derived antimicrobial peptides: increased potency by sequence engineering and dimerizationJournal of Antimicrobial Chemotherapy, 1999
- Antimicrobial Peptides as Mediators of Epithelial Host DefensePediatric Research, 1999
- Interaction of Cationic Peptides with Bacterial MembranesPublished by Springer Nature ,1996
- Mechanisms of antibacterial action of tachyplesins and polyphemusins, a group of antimicrobial peptides isolated from horseshoe crab hemocytesAntimicrobial Agents and Chemotherapy, 1992
- Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.Journal of Clinical Investigation, 1989
- Adaptive resistance to polymyxin in Pseudomonas aeruginosa due to an outer membrane impermeability mechanismCanadian Journal of Microbiology, 1982
- Electron microscopic observations of polysaccharide components in polymyxin B treated outer membranes from Serratia marcescens.The Journal of Antibiotics, 1979