The Response of Leukocytes in the Peripheral Blood During and Following Exchange Transfusion in the Newborn

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Abstract
Serial leukocyte counts were done on 12 full-term and eight premature jaundiced babies during exchange transfusions and daily thereafter until the ninth day, in order to study changes in each cell type. The main changes were found to be (1) a marked reduction in all cell types during the procedure with a statistically significant difference in absolute values before and after; (2) significantly lower values of the polymorphonuclear neutrophils and eosinophils in the baby's blood at the end of the transfusion compared with those of the donor's blood, with the monocytes and lymphocytes showing no statistically significant change; and (3) a remarkable rise in each cell type starting soon after the procedure and reaching a peak within the week following the transfusions. Comparison of absolute values during the post-transfusion days with those found in normal babies of corresponding postnatal age showed that the polymorphonuclear neutrophils and eosinophils were significantly increased, the lymphocytes unchanged, and the absolute values of monocytes decreased compared to those of normal babies.

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