EFFECT OF BOVINE PANCREATIC POLYPEPTIDE ON GASTRIC-ACID AND PEPSIN OUTPUT IN MAN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 25  (5) , 384-387
Abstract
Bovine pancreatic polypeptide [BPP] was infused i.v. in 16 healthy volunteers at a mean dose of 218 pmol/kg per hr, producing plasma levels similar to those after meals. Basal and pentagastrin-stimulated acid and pepsin outputs and plasma gastrin concentrations were unchanged by BPP. Pancreatic polypeptide is unlikely to be an important physiological modulator of these secretions in man.