Paramyxovirus Disruption of Interferon Signal Transduction: STATus Report
- 1 September 2009
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon & Cytokine Research
- Vol. 29 (9) , 531-537
- https://doi.org/10.1089/jir.2009.0070
Abstract
RNA viruses in the paramyxovirus family have evolved a number of strategies to escape host cell surveillance and antiviral responses. One mechanism exploited by a number of viruses in this family is direct targeting of cytokine-inducible transcription regulators in the STAT family. Diverse members of this large virus family effectively suppress STAT signaling by the actions of their V proteins, or the related proteins derived from alternate viral mRNAs. These viral proteins have distinct means of targeting STATs, resulting in a variety of negative effects on STATs and their signal transduction. Recent developments in understanding STAT targeting will be reviewed.Keywords
This publication has 77 references indexed in Scilit:
- Nipah Virus Edits Its P Gene at High Frequency To Express the V and W ProteinsJournal of Virology, 2009
- Measles Virus Circumvents the Host Interferon Response by Different Actions of the C and V ProteinsJournal of Virology, 2008
- STAT2 Is a Primary Target for Measles Virus V Protein-Mediated Alpha/Beta Interferon Signaling InhibitionJournal of Virology, 2008
- Henipavirus V Protein Association with Polo-Like Kinase Reveals Functional Overlap with STAT1 Binding and Interferon EvasionJournal of Virology, 2008
- Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATsJournal of General Virology, 2007
- A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different speciesJournal of General Virology, 2006
- Rinderpest Virus Blocks Type I and Type II Interferon Action: Role of Structural and Nonstructural ProteinsJournal of Virology, 2006
- Receptor (SLAM [CD150]) Recognition and the V Protein Sustain Swift Lymphocyte-Based Invasion of Mucosal Tissue and Lymphatic Organs by a MorbillivirusJournal of Virology, 2006
- The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesNature Immunology, 2004
- C Terminal CYS-RICH Region of Mumps Virus Structural V Protein Correlates with Block of Interferon α and γ Signal Transduction Pathway through Decrease of STAT 1-αBiochemical and Biophysical Research Communications, 2001