Strong Evidence of a Combination Polymorphism of the Tyrosine Kinase 2 Gene and the Signal Transducer and Activator of Transcription 3 Gene as a DNA-Based Biomarker for Susceptibility to Crohn’s Disease in the Japanese Population
Open Access
- 4 August 2009
- journal article
- research article
- Published by Springer Nature in Journal of Clinical Immunology
- Vol. 29 (6) , 815-825
- https://doi.org/10.1007/s10875-009-9320-x
Abstract
An association between susceptibility to inflammatory bowel disease (IBD) and polymorphisms of both the tyrosine kinase 2 gene (TYK2) and the signal transducer and activator of transcription 3 gene (STAT3) was examined in a Japanese population in order to identify the genetic determinants of IBD.Keywords
This publication has 42 references indexed in Scilit:
- Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn DiseaseAmerican Journal of Human Genetics, 2009
- Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibilityNature Genetics, 2008
- Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's diseaseNature Genetics, 2008
- Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's diseaseNature Genetics, 2008
- A second generation human haplotype map of over 3.1 million SNPsNature, 2007
- Unravelling the pathogenesis of inflammatory bowel diseaseNature, 2007
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature, 2007
- Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesisNature Genetics, 2007
- A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease GeneScience, 2006
- The Montreal classification of inflammatory bowel disease: controversies, consensus, and implicationsGut, 2006