Influences of Corticotropin-Releasing Hormone, Adrenocorticotropin, and Cortisol on Sleep in Normal Man*

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Abstract
We studied the effects of the hormones of the hypothalamus-pituitary-adrenocortical axis on sleep processes in normal men. In one experiment, 10 men received placebo, cortisol (6 mg/h), and ACTH (0.55 U/h) as continuous iv infusions from 2200–0700 h on 3 separate nights. In another experiment, placebo and CRH (30 μg/h) were administered to another 10 men in the same manner. The mean plasma cortisol levels were comparable during the cortisol and ACTH infusions (552 vs. 668 nmol/L). During both infusions, the time spent in rapid eye movement (REM) sleep was significantly (P < 0.01) reduced compared to that during the placebo infusion, and the cortisol infusion significantly (P < 0.05) enhanced the time spent in slow wave sleep (SWS). The CRH dose used only moderately increased plasma ACTH and cortisol levels; the changes in SWS and REM sleep during CRH infusion were in the same direction as occurred during the cortisol infusion, but were not significant. These results suggest that cortisol has a sleep modulatory effect. The decrease in REM sleep during the ACTH infusion may be mediated by the rise in endogenous cortisol. However, ACTH specifically altered sleep, in that it inhibited the cortisolinduced increase in SWS. Peripherally administered CRH had no intrinsic influence on sleep.

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