Eine neue Synthese von (S)-β-Methyl-γ-butyrolacton und (S)-4-Benzyloxy-3-methylbutansäure
- 1 January 1991
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1991 (10) , 832-834
- https://doi.org/10.1055/s-1991-26584
Abstract
A New Synthesis of (S)-β-Methyl-γ-butyrolactone and (S)-4-Benzyloxy-3-methylbutanoic Acid A stereoselective synthesis of (S)-β-methyl-γ-butyrolactone [(S)-4,5-dihydro-4-methyl-2(3H)-furanone, 1] and of (S)-4-benzyloxy-3-methylbutanoic acid (2) is described. Both compounds are prepared starting from inexpensive L-ethyl lactate with overall yields of 26% and 30%, respectively. The products are valuable chiral building blocks.Keywords
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