Predictive Molecular Pathology

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Abstract
The search for markers that can predict the outcome in an individual patient with cancer or the response of an individual tumor to specific therapies is a major focus of cancer research. Despite these efforts, estrogen and progesterone receptors and the HER2/neu gene are the only molecular targets that are analyzed routinely in newly diagnosed breast cancers. Thousands of studies of putative prognostic or predictive markers have failed to identify useful molecular markers in tumors, either because the selected genes were noninformative or because initially promising data could not be reproduced in other laboratories.The search for prognostic and predictive . . .

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