Serial Cell-Free Passage of a Radiation-Activated Mouse Leukemia Agent.
- 1 January 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 100 (1) , 102-105
- https://doi.org/10.3181/00379727-100-24538
Abstract
A filterable agent designated "virus X" recovered from a C3H female in which leukemia was induced by X-ray irradiation, was passed serially through 4 consecutive cell-free inoculations of suckling C3H mice. Of 40 mice inoculated, 26 thus far developed leukemia (65%) at average ages varying from 3 to 11 months. Inactivated (56[degree]C, 1/2 hour) rabbit and guinea pig serum, prepared with agent X filtrates, only partially neutralized passage A leukemic agent, whereas passage A immune serum had a distinct, though not complete neutralization effect on the passage A agent. The passage A agent had been previously reported (Gross, L.: Proc. Soc. Exptl. Biol. and Med. 94: 767-771, 1957); it originated from spontaneous Ak leukemia and has been passed by cell-free inoculations in newborn or suckling C3H mice.This publication has 2 references indexed in Scilit:
- High Susceptibility of 1 to 14 Days Old C3H Mice to "Passage A" Leukemic Filtrates.Experimental Biology and Medicine, 1958
- Development and Serial Cell-Free Passage of a Highly Potent Strain of Mouse Leukemia Virus.Experimental Biology and Medicine, 1957