Immune Reconstitution Syndrome after Successful Treatment ofPneumocystis cariniiPneumonia in a Man with Human Immunodeficiency Virus Type 1 Infection
Open Access
- 15 August 2002
- journal article
- case report
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 35 (4) , 491-493
- https://doi.org/10.1086/341974
Abstract
We describe a 34-year-old man with human immunodeficiency virus infection who received successful treatment of minimally symptomatic Pneumocystis carinii pneumonia and who subsequently developed diffuse pulmonary infiltrates and hypoxia 2 weeks after initiation of combination antiretroviral therapy. Initial pathologic evaluation of lung-tissue samples revealed no organisms, but a polymerase chain reaction assay was strongly positive for P. carinii DNA. We hypothesize that this patient's clinical presentation denotes immune reconstitution syndrome in response to residual P. carinii antigen in the lungKeywords
This publication has 8 references indexed in Scilit:
- Acute Respiratory Failure Following HAART Introduction in Patients Treated for Pneumocystis carinii PneumoniaAmerican Journal of Respiratory and Critical Care Medicine, 2001
- Immunorestitution Disease Involving the Innate and Adaptive ResponseClinical Infectious Diseases, 2000
- Clearance of Pneumocystis carinii Cysts in Acute P carinii PneumoniaChest, 1998
- Detection of Herpesvirus-Like DNA Sequences in Kaposi's Sarcoma in Patients with and Those without HIV InfectionNew England Journal of Medicine, 1995
- PATHOGENESIS AND HOST RESPONSE INPneumocystis cariniiPNEUMONIAAnnual Review of Medicine, 1994
- Kaposi's sarcoma in HIV-negative homosexual menThe Lancet, 1990
- Pneumocystis cariniiPneumonia: Differences in Lung Parasite Number and Inflammation in Patients with and without AIDSAmerican Review of Respiratory Disease, 1989
- Pneumocystis carinii Pneumonia: A Comparison Between Patients with the Acquired Immunodeficiency Syndrome and Patients with Other ImmunodeficienciesAnnals of Internal Medicine, 1984