Synthesis of Glycopeptides with LewisaAntigen Side Chain and HIV Peptide T Sequence Using the Trichloroethoxycarbonyl/Allyl Ester Protecting Group Combination
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (07) , 591-593
- https://doi.org/10.1055/s-1992-21427
Abstract
The N-glycosidic conjugate of the Lewisa antigen trisaccharide and an octapeptide sequence (peptide T) of gp 120 of HIV was synthesized using the 2,2,2-trichloroethoxycarbonyl (Teoc) group in combination with the allyl ester as the carboxy protection. These orthogonally stable protecting groups are selectively and alternatively removable under mild conditions without cleavage or anomerization of the glycosidic bonds.Keywords
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