Hemoglobin I Mutation Encoded at Both α-Globin Loci on the Same Chromosome: Concerted Evolution in the Human Genome
- 21 December 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 226 (4681) , 1449-1451
- https://doi.org/10.1126/science.6505702
Abstract
Genetic analysis of an individual expressing an unexpectedly high level of hemoglobin I, an alpha-globin structural mutant, reveals that the mutation is present at both the alpha 1- and the alpha 2-globin gene loci. Kindred analysis confirms that the two affected genes are located in cis. The most likely explanation for this finding is that a recent conversion event occurred within the human alpha-globin gene cluster.This publication has 34 references indexed in Scilit:
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