Treatment of Chemically-Induced Intestinal Cancers with Indomethacin

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Abstract
Intestinal tumors were induced in Lobund strain Sprague-Dawley rats by a single administration of 1,2-dimethylhydrazine (DMH) or of methylazoxymethanol acetate (MAM). At 34 days later (DMH), or at 7 and 35 days later (MAM), groups of rats were administered indomethacin (20 mg/l) in the drinking water. When examined at week 20, in those that consumed indomethacin, there was a significant reduction in numbers of rats with intestinal tumors compared to the control rats. In view of the interval between exposure to the carcinogen and treatment with indomethacin, the effect is interpreted as therapeutic or as antipromotional.

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