Bischler-Napieralski Reaction of C2′, Functionalized 1,2-Diarylethylamides: A General Approach to the Synthesis of Protoberberines

Abstract
A synthetic route towards the protoberberines is reported. The key transformations are derived from the intramolecular cyclization of C2′, functionalized 1,2-diarylethylamides under. Bischler-Napieralski reaction conditions. This procedure afforded the quinolizidine nucleus of these alkaloids in one-pot.

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