Anatomic and Histologic Changes in Rabbits with Experimental Hypersensitivity Treated with Compound E and ACTH

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Abstract
Compound E markedly suppresses the pathological alterations of the Arthus reaction ordinarily produced in the rabbit by repeated injns. of crystalline egg albumin. The adrenocorticotropic (ACTH) hormone exerted a decidedly less marked effect. Compound E and ACTH produced atrophy of the lymphoid tissues, including the thymus and spleen, and a lympho-cytopenia. These alterations were greater with Compound E and in addition, in the animals treated with this hormone, there were extensive deposition of glycogen and fat in the liver, a lipemia and focal necrosis of skeletal muscle. In the animals treated with Compound E the adrenals were small while in those treated with ACTH, the adrenals were enlarged but lacking in lipoid.

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