Dibutryl Cyclic Adenosine Monophosphate: Effect on Radiosensitivity of Tumors and Normal Tissues in Mice

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Abstract
The effect of dibutryl cyclic AMP (bd-cAMP, 30 mg/kg), injected into mice before irradiation, on the radiation sensitivity of various tissues was investigated. Survival of proliferating hair follicles, small gut stem cells, fibrosarcoma (FSa) micrometastases in the lungs and 2 different mammary carcinomas, as assayed by the TCD50 [median tissue culture (infective) dose] method, were studied. I.p. injection of db-cAMP before irradiation resulted in higher survival of hair follicles irradiated on the 3rd day after plucking. Stem cells in the small gut showed increased survival if irradiated 4 h after injection. There was no effect on the survival of FSa micrometastases by preinjection and the TCD50/120 days of the mammary carcinomas was not altered.