Cytotoxic and Radiosensitizing Effects of 5-Thio-d-Glucose on Hypoxic Cells
- 1 April 1977
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 123 (1) , 201-205
- https://doi.org/10.1148/123.1.201
Abstract
The effect of 5-thio-D-glucose on the viability and radiosensitivity of P815-X2 mouse mastocytoma cells was studied in vitro. By itself, this compound is specifically cytotoxic toward hypoxic cells. It sensitizes hypoxic cells to irradiation while it protects aerobic cells from radiation damage. These features, together with its low toxicity, suggest that 5-thio-D-glucose may be a useful adjuvant to radiotherapy.This publication has 0 references indexed in Scilit: