Distribution of Calcitonin-Containing Cells in the Normal Adult Human Thyroid Gland: A Correlation of Morphology with Peptide Content
- 1 April 1974
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 38 (4) , 688-694
- https://doi.org/10.1210/jcem-38-4-688
Abstract
The distribution of C-cells in the adult human thyroid gland was mapped by a combination of immunoperoxidase localization, biological assay and radioimmunoassay. C-cells are concentrated along the central axis of the lateral lobes in their middle thirds and are predominantly distributed individually in parafollicular and intrafollicular locations. The relative numbers of C-cells observed per unit area of thyroid tissue correlated strongly with the calcitonin content of immediately adjacent tissue sections. The total ranges determined were from fewer than 2 immunoperoxidase-staining cells per low power field (calcitonin content < 0.50 to 5.0 MRC mU/g fresh weight) in the extremes of the upper and lower poles to 4–10 stained cells per low power field (10 to 160 MRC mU/g) in the midportions of the lateral lobes.Keywords
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