Endodontic leakage studies reconsidered. Part I. Methodology, application and relevance

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Abstract
An increasing number of endodontic leakage studies have been published. In the 1990 volumes of Journal of Endodontics and International Endodontic Journal, there was one leakage study to every 4.3 scientific articles. The most popular method was linear measurement of tracer (dye or radioisotope) penetration along a root filling. Comparing some data on linear measurement of dye penetration following the cold lateral condensation of gutta-percha that were published between 1980 and 1990, a high level of variation has been found, although the experimental methods used in these studies were quite similar. In almost all studies evaluating various techniques, the cold lateral condensation technique has been used as a standard control for comparison. The reliability of these results is questionable. The problems with such studies are discussed. It seems that more research should be done on leakage study methodology, instead of continuing to evaluate the sealing ability of different materials and techniques by methods that may give little relevant information.