Treatment of Rheumatoid Arthritis with Prostaglandin E1, Precursors CIS-Linoleic Acid and γ-Linolenic Acid
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 12 (2) , 85-88
- https://doi.org/10.3109/03009748309102890
Abstract
20 patients with active rheumatoid arthritis were treated for 12 weeks with the prostaglandin E, precursors cis-linoleic acid and γ-linolenic acid in the form of primrose evening oil (Efamol®) and the co-factors zinc, ascorbic acid, niacin, and pyridoxin (Efavit®). There was a slight fall in skin reactivity to UV light during the treatment, but no effect on plasma or urine concentrations of PGE1, cAMP or cGMP. There was no effect of the treatment on ESR, P-fibrinogen, number of tender joints, number of swollen joints, the duration of morning stiffness, or on the patient's estimation of pain.This publication has 14 references indexed in Scilit:
- RHEUMATOID ARTHRITIS: A DISEASE OF T-LYMPHOCYTE/MACROPHAGE IMMUNOREGULATIONThe Lancet, 1981
- Suppression of acute and chronic inflammation by orally administered prostaglandinsArthritis & Rheumatism, 1981
- TREATMENT OF ATOPIC ECZEMA WITH EVENING PRIMROSE OILThe Lancet, 1981
- The regulation of prostaglandin biosynthesis: Negative feedback mechanisms and the selective control of formation of 1 and 2 series prostaglandins: Relevance to inflammation and immunityMedical Hypotheses, 1980
- Sjogren's syndrome and the sicca syndrome: The role of prostaglandin El deficiency. Treatment with essential fatty acids and vitamin CMedical Hypotheses, 1980
- PROSTAGLANDINS IN THE RHEUMATIC DISEASES*Annals of the New York Academy of Sciences, 1975
- Radioimmunoassay of Prostaglandins Fα, E1 and E2 in Human PlasmaEuropean Journal of Clinical Investigation, 1975
- Intradermal Anti-Prostaglandin Agents and SunburnJournal of Investigative Dermatology, 1974
- Radioimmunoassay for Cyclic NucleotidesJournal of Biological Chemistry, 1972
- Inactivation of Prostaglandins by the LungsNature, 1970