On the Possible Relationship between Diarrhoea and o-Chlorobenzylidene Malononitrile (CS)

Publisher Website
Google Scholar
Abstract
Several species of animal were given single doses of CS, dissolved in polyethylene glycol 300, by stomach tube and their stools subsequently examined for consistency. Wet stool production was seen infrequently, and occurred in both CS-treated animals and controls receiving the solvent alone. In another group of animals given 5 consecutive daily doses of CS by stomach tube, only 4 out of 21 animals had minimal lesions of the gastric mucosa, but there was no evidence of an irritant effect on the intestine. Furthermore, the repeated dosing of animals with CS did not cause detectable lesions in lung, liver, kidney, spleen, pancreas, or adrenal gland. In a series of inhalation experiments, rabbits exposed to thermally-generated CS did not show any evidence of an increase in the amount of material defaecated or its water content. There is no evidence from the experiments reported here that exposure to CS smokes can cause a diarrhoea-like condition; this is discussed.

This publication has 3 references indexed in Scilit: