Hematopoietic Stem Cell TransplantationA Global Perspective

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Abstract
Hematopoietic stem cell transplantation (HSCT) has become the standard of care for many patients with defined congenital or acquired disorders of the hematopoietic system or with chemosensitive, radiosensitive, or immunosensitive malignancies.1-3 Over the last 2 decades, HSCT has seen rapid expansion in use and a constant evolution in its technology. Novel indications are currently under evaluation.4,5 Bone marrow is supplemented as a stem cell source by peripheral blood or cord blood. More than 14 million typed volunteer donors or cord blood units from the many registries worldwide provide stem cells for patients without family donors. Novel conditioning regimens with lower intensity have expanded the use of HSCT to older patients and to those with comorbidities.6-9