Short report: clarithromycin, an alternative to metronidazole in the triple therapy of Helicobacter pylori infection
- 1 February 1994
- journal article
- clinical trial
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 8 (1) , 131-134
- https://doi.org/10.1111/j.1365-2036.1994.tb00170.x
Abstract
SUMMARY: Background: Triple therapy for Helicobacter pylori using metronidazole is less effective in patients with a metronidazole resistant strain. Moreover, metronidazole is responsible for many side‐effects. This open study examined the efficacy and side‐effects of a triple treatment regimen substituting clarithromycin for metronidazole. Methods: 36 patients with a H. pylori infection, proven by culture, were treated with tripotassium dicitrato bismuthate 120 mg q.d.s., tetracycline 250 mg q.d.s. and clarithromycin 250 mg q.d.s. for 10 days.Eradication was defined as a negative culture and histological examination of antral biopsy specimens, taken at least 6 weeks after completion of the treatment. Results: Eradication was achieved in 26 patients (72%). The treatment was well tolerated with only 4 (11 %) of the patients having significant side‐effects. Conclusion: Triple therapy with clarithromycin seems to be less effective than standard triple treatment when the prevalence of metronidazole resistance is low. It is suggested, however, that this combination could be a valuable alternative in areas with a high prevalence of metronidazole resistance.Keywords
This publication has 24 references indexed in Scilit:
- Clarithromycin for the Eradication of Helicobacter PyloriJournal of Clinical Gastroenterology, 1993
- Amoxicillin added to omeprazole prevents relapse in the treatment of duodenal ulcer patientsEuropean Journal of Gastroenterology & Hepatology, 1993
- Clinical efficacy of triple therapy in Helicobacter pylori-associated duodenal ulcerEuropean Journal of Gastroenterology & Hepatology, 1993
- Decreased relapse rate after antibacterial treatment of Helicobacter pylori-associated duodenal ulcers. Munich duodenal ulcer trialEuropean Journal of Gastroenterology & Hepatology, 1993
- Treatment of Peptic Ulcers Caused by Helicobacter pyloriNew England Journal of Medicine, 1993
- Amoxicillin plus omeprazoleEuropean Journal of Gastroenterology & Hepatology, 1993
- Efficacy and Side Effects of a Triple Drug Regimen for the Eradication of Helicobacter pyloriScandinavian Journal of Gastroenterology, 1993
- Helicobacter pylori and peptic ulcers: the present position.Gut, 1992
- One week eradication regimen for Helicobacter pyloriThe Lancet, 1991
- Susceptibility of Campylobacter pylori to macrolides and fluoroquinolonesJournal of Antimicrobial Chemotherapy, 1988