Plasma histamine concentrations in atopic eczema

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Abstract
Plasma histamine concentrations were determined using a radio-enzymatic assay in 54 patients suffering from atopic eczema and in 39 controls (contact dermatitis, psoriasis and normal non-atopic healthy volunteers). While in none of the controls histamine levels in plasma exceeded 1 ng/ml, 17 of 54 patients with atopic eczema showed increased plasma histamine concentrations ranging between 1.2 and 5.2 ng/ml. Elevated plasma histamine levels were found mostly in patients with severe eczema and high serum IgE levels. Longitudinal studies in 7 patients revealed normal plasma histamine values during clinical remission.