CYCLIC-NUCLEOTIDES OF CONE-DOMINANT RETINAS - REDUCTION OF CYCLIC-AMP LEVELS BY LIGHT AND BY CONE DEGENERATION
- 1 January 1981
- journal article
- research article
- Vol. 20 (1) , 24-31
Abstract
Dark-adapted retinas or whole eyes of 13-line ground squirrels (Citellus tridecemlineatus) and western fence lizards (Sceloporus occidentalis) contain higher levels of cAMP than cGMP. In these cone-dominant retinas, light reduces cAMP content selectively. Freezing of dark- or light-adapted retinas or eyes reduces cAMP content, with only minimal changes in cGMP levels. Exposure of frozen retinas of dark-adapted ground squirrel to light results in a significant decrease in cAMP content. The destruction of cone visual cells of ground squirrel retina by iodoacetic acid injection decreases the cyclic nucleotide content of the dark-adapted retina. Considering the relative loss of cyclic nucleotides from cone degeneration, the content of cAMP in visual cells of ground squirrel retina is about 4 times greater than cGMP.This publication has 6 references indexed in Scilit:
- CYCLIC NUCLEOTIDE LEVELS IN NORMAL AND BIOLOGICALLY FRACTIONATED MOUSE RETINA: EFFECTS OF LIGHT AND DARK ADAPTATIONJournal of Neurochemistry, 1978
- DIFFERENTIAL EFFECT OF RD MUTATION ON RODS AND CONES IN MOUSE RETINA1978
- LIGHT‐INDUCED REDUCTION IN CYCLIC GMP OF RETINAL PHOTORECEPTOR CELLS IN VIVO: ABNORMALITIES IN THE DEGENERATIVE DISEASES OF RCS RATS AND rd MICE1Journal of Neurochemistry, 1977
- Distribution of 3':5'-cyclic AMP and 3':5'-cyclic GMP in rabbit retina in vivo: selective effects of dark and light adaptation and ischemia.Proceedings of the National Academy of Sciences, 1976
- Cyclic GMP: Control of concentration by light in retinal photoreceptorsBiochemical and Biophysical Research Communications, 1976
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951