Influence of gluten‐derived fractions on chemiluminescence production by human neutrophils

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Abstract
The effects of gliadin and glyc‐gli on leukocyte chemiluminescence response were assessed in vitro. A dose‐dependent increase in chemiluminescence response of neutrophils stimulated by zymosan was observed by using gliadin at concentrations ranging between 1 and 20 μg. By increasing glyc‐gli concentration, a bimodal response was observed with an enhancement up to 50 μg/ml, followed by suppressive effects, which were again dose‐dependent. The possible implications of these findings in human pathology are discussed.