Studies on Essential Fatty Acid Deficiency in Three Strains of Mice

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Abstract
Essential fatty acid deficiency has been studied in mice of the C57 black, C3H, and dba strains. The most characteristic symptoms were: dermatitis of the skin and extremities, scaliness of the ears, alopecia, a neck lesion, and retardation of growth. Pre-depletion of the weanlings, produced by placing the mother on a deficient diet during the lactation period, had a marked effect on the time of development of the symptoms. The dba strain was found to be more sensitive to the deficiency than the C3H or C57 strains. Prophylactive and curative experiments indicate that under the experimental conditions used 5 mg of methyl linoleate per day satisfy the requirement of the mouse for linoleic acid.

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