Combining sugar biosynthesis genes for the generation ofl- andd-amicetose and formation of two novel antitumor tetracenomycins
- 27 January 2005
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 12,p. 1604-1606
- https://doi.org/10.1039/b417815g
Abstract
L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.Keywords
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