Acetylcholine does not stimulate the release of growth hormone from perifused rat adenohypophyses

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Abstract
Acetylcholine (1 μmol/L − 1 mmol/L) has been reported to stimulate growth hormone release from perifused bovine pituitary slices. We have carried out studies using the perifused pars distalis of the rat adenohypophysis to see whether a similar response is observed. Neither acetylcholine, acetylcholine with eserine, nor carbamylcholine, at concentrations of 10−9, 10−6, and 10−3 M, stimulated the release of growth hormone. Thus we could not demonstrate a similar response to acetylcholine in the pars distalis of the rat adenohypophysis as reported in the bovine gland.

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