K65R and Y181C are less prevalent in HAART-experienced HIV-1 subtype A patients
- 4 November 2005
- journal article
- research article
- Published by Wolters Kluwer Health in AIDS
- Vol. 19 (16) , 1916-1919
- https://doi.org/10.1097/01.aids.0000189860.36688.e5
Abstract
The vast majority of HIV-1 infections globally are caused by subtype A or C, although little is known about their drug resistance profiles. We found that HAART-experienced patients infected with subtype A had a lower prevalence of K65R and Y181C than those with subtypes B or C, despite similar exposure to antiretroviral agents that select for these mutations. If confirmed, this information may be important in the planning of antiretroviral regimens in patients infected with HIV-1 subtype A.Keywords
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