Endothelial and Epithelial-Like Cell Formations in a Case of Posterior Polymorphous Dystrophy

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Abstract
• Histology of the endothelial and epithelial-like cells, vesicles, and membranes seen on the posterior corneal surface in posterior polymorphous dystrophy were examined by light microscopy and scanning and transmission electron microscopy in a 3-month-old female infant. The entire posterior surface of both corneas was covered by a geographic pattern of endothelial and epithelial-like cells, sometimes creating vesicles and sometimes creating partially detached sheets of cells. The thickness of Descemet's membrane varied widely, showing a tendency to be most complete under the remaining endothelial cells and thinner or absent under the epithelial-like cells. Details of this histology have important implications for our understanding of congenital diseases of corneal endothelium.