Neostatin‐7 regulates bFGF‐induced corneal lymphangiogenesis
Open Access
- 18 June 2008
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 582 (17) , 2515-2520
- https://doi.org/10.1016/j.febslet.2008.06.014
Abstract
Neostatin‐7, with an anti‐angiogenic potential, is generated from the proteolytic action of matrix metalloproteinase‐7 on collagen XVIII. We previously reported that neostatin‐7 inhibited angiogenesis in vitro and in vivo. Here we demonstrate that neostatin‐7/collagen XVIII may possess anti‐lymphangiogenic activities by: (1) corneal micropellet implantation of neostatin‐7 reduced bFGF‐induced corneal lymphangiogenesis; (2) neostatin‐7 bound to VEGF receptor‐3 in vitro; and (3) enhanced corneal lymphangiogenesis and VEGF‐C expression in collagen XVIII knockout mice in a corneal wounding model. Understanding the mechanism of neostatin‐7/collagen XVIII on corneal lymphangiogenesis may provide therapeutic interventions to treat lymphangiogenesis‐related disorders, such as lymphedema, transplantation rejection and cancers.Keywords
This publication has 34 references indexed in Scilit:
- Generation of Endostatin by Matrix Metalloproteinase and Cathepsin from Human Limbocorneal Epithelial Cells Cultivated on Amniotic MembraneInvestigative Opthalmology & Visual Science, 2007
- Corneal avascularity is due to soluble VEGF receptor-1Nature, 2006
- Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and visionProceedings of the National Academy of Sciences, 2006
- Endostatin competes with bFGF for binding to heparin-like glycosaminoglycansBiochemical and Biophysical Research Communications, 2005
- Inhibition of Lymphogenous Metastasis Using Adeno-Associated Virus-Mediated Gene Transfer of a Soluble VEGFR-3 Decoy ReceptorCancer Research, 2005
- Functional characterization of neostatins, the MMP‐derived, enzymatic cleavage products of type XVIII collagenFEBS Letters, 2005
- Loss of Collagen XVIII Enhances Neovascularization and Vascular Permeability in AtherosclerosisCirculation, 2004
- Increased Angiogenic Response in Aortic Explants of Collagen XVIII/Endostatin-Null MiceThe American Journal of Pathology, 2004
- New insights into the biology and pathology of the cutaneous lymphatic systemJournal of Dermatological Science, 2004
- Corneal Neovascularization after Excimer Keratectomy Wounds in Matrilysin-Deficient MiceInvestigative Opthalmology & Visual Science, 2003